Laser Facial Nerve Welding in a Rabbit Model
Author Affiliations: Division of Facial Plastic & Reconstructive Surgery, Department of Otolaryngology, New York University Langone Medical Center, New York (Dr Bloom); Department of Otolaryngology–Head & Neck Surgery, Harvard Medical School, and Massachusetts Eye and Ear Infirmary, Boston (Dr Bleier); Divisions of Otolaryngology and Facial Plastic & Reconstructive Surgery, Department of Surgery, University of Arizona, Tucson (Dr Goldstein); Carniol Research Center, Summit, New Jersey (Dr Carniol); and Department of Otorhinolaryngology–Head and Neck Surgery, University of Pennsylvania, Philadelphia (Drs Palmer and Cohen). AbstractObjective To assess the feasibility of laser tissue welding for repair of facial nerve injury.
Methods In a prospective in vivo animal survival surgery model, rabbit facial nerve injury was followed by either standard suture neurorrhaphy or laser tissue welding using a diode laser (808 ± 1 nm) to weld biological solder. Rabbits were evaluated at 4, 8, 12, and 16 weeks by facial videography and electromyography. Histopathological analysis of the repair was performed at 4 and 16 weeks.
Results Videographic analysis demonstrated the laser tissue welding repair trended toward superior outcomes compared with suture neurorrhaphy at all 4 time points. Electrophysiological analysis demonstrated similar or better results, with statistically significant improvement at week 16 ( P < .05). Histologic analysis demonstrated no difference in axon organization or extravasation between groups; however, the laser nerve repair created a greater initial inflammatory reaction. An analysis of operative time demonstrated significantly decreased time and ease of use for laser tissue welding.
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Objective To assess the feasibility of laser tissue welding for repair of facial nerve injury. Methods In a prospective in vivo animal survival surgery model, rabbit facial nerve injury was followed by either standard suture neurorrhaphy or laser
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