Professor Geoffrey Ozin is 2011 Barrer Award Recipient
This research has since gone on to spawn a whole field of scientific endeavor, touching areas such as sensing, energy, and even healthcare: some of the latest breakthroughs in the field include nanocrystalline tin that stores the lithium for Li-ion batteries in its pores, and the nanoporous silicon microparticles that ferry therapeutic nanoparticles to bone marrow.Totally New Approach To Cancer Therapy ~ Science Today
Now, what if the sink was a cancer cell, the globs of grease were cancer-promoting proteins and the dish soap was a potential drug? According to new research from the University of Toronto Mississauga, such a drug could force the proteins to the cell's membrane (a.k.a., the edge of the sink) -- and make the cancer cell more vulnerable to chemotherapy. "This is a totally new approach to cancer therapy," says Professor Patrick Gunning of the Department of Chemical and Physical Sciences. "Everything prior to this has targeted functionally relevant binding sites. Our approach inhibits the mobility of cancer-promoting proteins within cells -- essentially, it's like molecularly targeted glue." The "glue" is shaped like a dumbbell: at one end is an anchor that sticks to the membrane, and at the other is a molecule that binds to the cancer-promoting proteins. The anchor is a cholesterol molecule that is well known to chemists for sticking to cell membranes. The protein recognition molecule is fairly picky about what it will bind to, reducing the risk of drug-related side effects. "We are really excited about the potential for this type of drug," says Gunning, who developed the concept along with Professor Claudiu Gradinaru at U of T Mississauga and Professor James Turkson at the University of Central Florida. "This is ready to move to preclinical studies, and this treatment could slow or stop the explosive growth of cancerous tumours. And for patients, this might reduce the need for really powerful chemotherapy, which can be very hard to tolerate.
Angewandte Chemie University Of Toronto - Bookshelf
Of mice and men
The tragic story of the friendship between two migrant workers, George and mentally retarded Lenny, and their dream of owning a farmThree cups of tea, one man's mission to fight terrorism and build nations-- one school at a time
Traces how the author, having been rescued and resuscitated by Himalayan villagers after a failed attempt to climb K2, worked to build schools that would ...Art of War
While appreciative of the philosophical richness of the Art of War, this edition stresses Sun-tzu's practical origins and presents a translation that is both ...The elements of style
Offers advice on improving writing skills and promoting a style marked by simplicity, orderliness, and sincerity.In defense of food, an eater's manifesto [additional copies -- 2]
Cites the reasons why people have become so confused about their dietary choices and discusses the importance of enjoyable moderate eating of mostly traditional ...Web Information Directory
Polytellurophenes with Properties Controlled by Tellurium ...
Angewandte Chemie International Edition, 49: 10140–10144. doi: 10.1002/anie.201005664 ... was supported by the University of Toronto and the National Science ...
Programmed Nanoparticle Aggregation Using Molecular Beacons ...
Angewandte Chemie International Edition, 49: 7917–7919. doi: 10.1002/anie.201003846 ... of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, ...
All the Colors of the Rainbow
As they report in the journal Angewandte Chemie, this material could be useful for the production of ... University of Toronto (Canada) and Ian Manners at the University of ...
Molecular glue to impart cutting edge to chemotherapy ...
When you drop a cake of soap into a sink full of greasy water, the grease recoils and retreats to the edges of the sink.
Frustrated Pair Captures CO2
Novel concept for the binding of carbon dioxide without a metal-containing catalyst. ... Angewandte Chemie, the team led by Gerhard Erker and Stefan Grimme at the University of ...